Journal: STAR Protocols

Article Title: Protocol for applying Tumor Treating Fields in mouse models of cancer using the inovivo system

doi: 10.1016/j.xpro.2024.103535

Figure Lengend Snippet: Get to know the inovivo system components and set up the system Arrays (A). Generators (B). Swivels (C, for a better view of the display refer to D). Cages (D). Software screenshots before and after connecting 1 of 5 possible generators and 4 of 8 possible mice/swivels (4 dual cages), new/start/end experiment indicated with yellow/orange/black arrows, respectively (E). Scheme of a fully connected inovivo system (F). The desktop software icon (G).

Article Snippet: inovivo roll of adhesive strips , Novocure , N/A.

Techniques: Software

Journal: STAR Protocols

Article Title: Protocol for applying Tumor Treating Fields in mouse models of cancer using the inovivo system

doi: 10.1016/j.xpro.2024.103535

Figure Lengend Snippet: Connect the mice to the inovivo system and start the experiment Place the mouse in the cage once it is awake (A); Gently connect the array connector to the array plug on the bottom of the swivel (B); Verify swivel-array and generator-swivel connections in the software and on the swivel display (C and D); Examine the software interface to verify the experiment has started by the appearance of two “turning wheels” (indicated with yellow arrows) and measured parameters for the cages (indicated with an orange arrow for cage 1 as an example) (E), and that it has reached a steady state (F). For experimental control there is a master End Experiment button (indicated with a black arrow), and Pause, Resume, and End Experiment buttons per each cage (indicated with a red, green, and blue arrows, respectively, for cage 1 as an example) (F).

Article Snippet: inovivo roll of adhesive strips , Novocure , N/A.

Techniques: Software, Control

Journal: STAR Protocols

Article Title: Protocol for applying Tumor Treating Fields in mouse models of cancer using the inovivo system

doi: 10.1016/j.xpro.2024.103535

Figure Lengend Snippet: Turn on the inovivo system and set experimental conditions Use the inovivo software to set the treatment parameters: Press New Experiment (indicated with a yellow arrow) (A); In the opened window, insert experiment name, owner, and description (B); Set generator experimental parameters, selecting the animal type (mouse/rat, indicated with a green arrow) and experiment mode (TTFields/heat, indicated with a blue arrow) for each generator (C). Set first cage experimental parameters, selecting the frequency and target temperature (D and E); Copy the parameters to the other cages (F).

Article Snippet: inovivo roll of adhesive strips , Novocure , N/A.

Techniques: Software

Journal: STAR Protocols

Article Title: Protocol for applying Tumor Treating Fields in mouse models of cancer using the inovivo system

doi: 10.1016/j.xpro.2024.103535

Figure Lengend Snippet: Assemble the torso orthotopic inovivo arrays to the mice torsos The required materials and equipment: roll of adhesive strips, tweezers, scissors, and array (A), and the procedure steps: Spread the array on the surface and verify the ceramic disks are intact (B); Peel the center liner (C); Place the mouse with its back on the center of the array with the tail pointing at the direction of the PCB wire (D); Attach the side of the array adhesive tape to the mouse skin (E); Peel the side liner from the array left wing (F); Wrap the wing around the animal torso, and attach it to array exterior (G); Repeat for the adhesive right wing; Prepare 2 adhesive strips (H); Attach the strip with no opening to the upper side of the array (I); Attach the strip with an opening to the lower side of the array (J).

Article Snippet: inovivo roll of adhesive strips , Novocure , N/A.

Techniques: Adhesive, Stripping Membranes

Journal: STAR Protocols

Article Title: Protocol for applying Tumor Treating Fields in mouse models of cancer using the inovivo system

doi: 10.1016/j.xpro.2024.103535

Figure Lengend Snippet: Assemble the subcutaneous inovivo arrays to the mice torsos The required materials and equipment: array caps, roll of adhesive strips, scissors, tweezers, and array (A), and the procedure steps: Spread the array on the surface and verify the ceramic disks are intact (B); Peel the center liner (C); Place the mouse on its stomach and place the array such that the tumor is located in the center of the circular opening in the array, with the PCB wire pointing in the same direction as the animal tail (D); Attach the sides of the array adhesive tape to the mouse skin (E); Peel the side liner from the array left wing (F); Wrap the wing around the animal torso, and attach it to array exterior (G); Repeat for the adhesive right wing; Prepare 2 adhesive strips (H); Attach the strip with no opening to the upper side of the array (I); Attach the strip with an opening to the lower side of the array (J); Remove a protective cap from the roll (K); Attach the cap on the tumor (L).

Article Snippet: inovivo roll of adhesive strips , Novocure , N/A.

Techniques: Adhesive, Stripping Membranes

Journal: STAR Protocols

Article Title: Protocol for applying Tumor Treating Fields in mouse models of cancer using the inovivo system

doi: 10.1016/j.xpro.2024.103535

Figure Lengend Snippet:

Article Snippet: inovivo roll of adhesive strips , Novocure , N/A.

Techniques: Recombinant, Adhesive, Sterility, Software